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Poor/Intensive Metabolizers, CYP2D6 The development with the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Approximately seven% on the inhabitants has decreased exercise of the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme process. These folks are “poor metabolizers” of debrisoquine, dextromethorphan and tricycli